As the successor of the highly-discussed DMAA, the stimulant we’ll review for you today still remains in many popular Sports Dietary Supplements. The substance we will be reviewing for you today is called DMHA, also known as “Octodrine” a well-sold fat-burning CNS stimulanting supplement that’s being used by many athletes for a “better” workout. The use of DMHA is an alternative to similar supplements and molecular structures like AMP citrate (DMBA) or DMAA that’s being contained in many pre-workout supplements while offering a few benefits at a little risk. However, there are also downsides of the “DMAA Successor”. Looking at the formula shows that DMHA has around 80% of the strength of DMBA while this stimulant has about 80% similarity compared to the DMAA formula.
What is DMHA?
DMHA (dimethylhexylamine), also called 2-aminoisoheptane or simply “octodrine”, is a psychoactive central nervous system stimulant. There are already two forms of DMHA, which are known as:
- 2-amino-6-methylheptane (synthetic DMHA)
- 2-amino-5-methylheptane (naturally occurring DMHA)
The natural version, 2-amino-5-methylheptane, is more expensive in production but also appears to be more useful to consumers than the synthetic version. Athletes have spoken in favor of the natural version, which seems to lead to a way better experience than the synthetic one. Many pre-workout supplements contain DMAA or have been “updated” to DMHA.
How DMHA works – The DMAA successor
As the successor of DMAA Octodrine has a very similar molecular structure to other psychoactive stimulants such as DMBA (AMP Citrate) and ephedrine.
DMAA, DMBA (AMP citrate) and DMHA have a methyl group on their alpha carbon each. This group appears to inhibit the monoamine oxidase enzyme activity what is responsible for the degradation of monoamines in your body. This methyl group also increases the potency of DMHA while improving the absorption in the blood-brain barrier. An increase of the interaction between catecholamines and target transporter then leads to an enhanced stimulant effect. Overall DMHA is a psychoactive stimulant that might make you feel better, stronger, increase your focus and more.
Where does DMHA come from?
DMHA can be naturally extracted from a fruit called “Kigelia Africana” or can be found in the bark from the Juglans Regia tree. In the past, people wrongly thought that the common source of DMHA is “Aconitum Kusnezoffii”. In fact, it’s a highly toxic plant and can kill you. However, DMHA as 2-amino-6-methylheptane is fully synthetic.
What are the benefits of DMHA?
DMHA has been shown to be an ideal workout supplement. Many users have reported that they are able to train beyond their usual point of fatigue and make huge progress than they never had before. They get new energy levels and have the possibility to increase the pain threshold for better results. Studies on animals have shown that DMHA aids intense workouts by decries the rate of perceived exertion.
DMHA can also be used to help support fat loss and is therefore suitable as an appetite suppressant. It reduces increasingly ravenous appetite and helps you to continue your diet successfully. DMHA is banned because of structural similarity to already banned substances. The use of the supplement is not recommended during sports competitions.
The supplement increases activity in the brain and improves the cognitive function. DMHA might boost your memory and creativity but also your motivation to work. For some individuals it appeared to help against depression trough chaning their mood in positive vibes. overall However, you can deal better with stress through a new level of mental alertness many athletes swear.
DMHA elevates Mood
DMHA might be helpful for people that suffer from mental fatigue or mild depression. It appears to elevate mood as it also increases mental alertness and reduces feelings of anxiety to some individuals.
DMHA can be useful for people with a high risk of colds. A sore throat or a runny nose are symptoms of a common cold or an allergic reaction. DMHA may reduce the chances of getting infections and boost the healing process. The supplement softens the swollen membranes because of narrowing blood vessels that supply the nostrils. DMHA also appears to aid patients with diseases such as Alzheimer or Parkinson and chronic diseases.
Thermogenesis is the production of heat in the organism by burning calories. DMHA can promote weight loss and burn more excess fats.
DMAA vs DMHA
DMHA vs DMAA: What’s the better stimulant for athletes? When you compare the molecular structure of DMAA, DMBA, and DMHA you’ll notice that their formulas are similar to each other. As DMBA appeared to be the direct successor but was still too similar to DMAA it got banned from big sports event such as the Olympics, Tour de France, …
DMHA is still allowed on lots of such events because it’s molecular structure is slightly different when directly compared to DMAA what might make it less unhealthy when consumed on a regular basis many athletes think. However, as DMHA is a really new substance there’ve not been that many studies that would prove which one of the two substances is better for your health.
Recommended Dose of DMHA
As there is no official dosing table available for this supplement we can only look at what results of animal studies have brought. According to many bodybuilders, the best time for DMHA intake is about 30-45 minutes before workout. Because this stimulant increases your overall energy level it will make you feel less appetite. Drinking enough water while the workout is very important because the stimulant will make you feel less thirsty.
According to PriceplowBlog 100-150mg orally appears to be a good dosage. Because the appropriate dose of DMHA depends on many factors such as user’s health, age and other conditions and individuals might react differently on this stimulant common doses range from 40mg-240mg.
DMHA Side Effects
There are no reliable data or studies on how the safety of DMHA consumption. As DMHA seems to be one of the successors of DMAA with about 85% of it’s molecular structure and potency there might also appear similar side effects. It is believed that the substance causes the same effects as molecular structures that are similar such as DMBA and DMAA “Geranium”. Possible side effects are increased blood pressure, increased heart rate and shortness of breath. It is recommended to begin with a very conservative amount before increasing the dose. It is important to find your personal limit and have a healthy and balanced diet. There are reports of a person that died because of an overdose in combination with other drugs.
High blood pressure
As stimulant DMHA can increase your blood pressure. If you already have high blood pressure, better avoid taking it.
Because Octodrine increases your blood-pressure it might cause blood vessels to constrict. So we strongly recommend to never take DMHA if you have glaucoma.
DMHA might cause blood vessels to constrict what would worse some types of glaucoma. So avoid taking octodrine if you have glaucoma.
Irregular heartbeat (arrhythmia)
Because Octodrine has stimulant effects like increasing heart rate and blood pressure it could worse heart arrhythmias.
As Octodrine might have increased blood pressure and heart rate it’d be a bad idea to take it before or directly after surgery.
DMBA is illegal in many countries around the globe because of its structural similarity to already banned substances. It is legally permissible in a few parts of Europe and America. While selling DMAA in Europe appears to be illegal in some countries it’s successor seems to be fully legal in most countries there as it’s only a sports nutrition supplement.
Thoughts on DMHA
As the successor of DMAA and DMBA, the new stimulant appears to offer lots of benefits to athletes and bodybuilders. Their variety goes from feeling stronger, over increased mental alertness to just having a better focus. It’s strongly recommended to combine DMHA with Caffeine, BCAAs, creatine and added protein to get the best results possible for your workout. However, there’s not been done that much research on DMHA so just be careful.
Always keep in mind that we are no doctors and are not going to give you personal advice on DMHA.